DIN Standards Committee Radiology
Radiological protection - Performance criteria for laboratories using the cytokinesis-block micronucleus (CBMN) assay in peripheral blood lymphocytes for biological dosimetry (ISO 17099:2024); German version EN ISO 17099:2024
Abstract
This document gives guidance on: a) confidentiality of personal information for the customer and the laboratory; b) laboratory safety requirements; c) calibration sources and calibration dose ranges useful for establishing the reference doseresponse curves that contribute to the dose estimation from CBMN assay yields and the detection limit; d) performance of blood collection, culturing, harvesting, and sample preparation for CBMN assay scoring; e) scoring criteria; f) conversion of micronucleus frequency in BNCs into an estimate of absorbed dose; g) reporting of results; h) quality assurance and quality control; i) informative annexes containing sample instructions for customers, sample questionnaire, a microscope scoring data sheet, and a sample report. This document excludes methods for automated scoring of CBMN.
Begin
2025-09-15
WI
00430095
Planned document number
DIN EN ISO 17099
Project number
08000451
Responsible national committee
Responsible european committee
CEN/TC 430 - Nuclear energy, nuclear technologies, and radiological protection
Responsible international committee
ISO/TC 85/SC 2/WG 18 - Biological and physical retrospective dosimetry
