NA 080

DIN Standards Committee Radiology

Project

Radiological protection - Performance criteria for service laboratories performing biological dosimetry by cytogenetics - The dicentric assay (ISO/DIS 19238:2022); German and English version prEN ISO 19238:2022

Abstract

This document provides criteria for quality assurance and quality control, evaluation of the performance, and the accreditation of biological dosimetry by cytogenetic service laboratories using the dicentric assay performed with manual scoring. This document addresses a) the confidentiality of personal information, for the requestor and the service laboratory, b) the laboratory safety requirements, c) the calibration sources and calibration dose ranges useful for establishing the reference dose-effect curves that contribute to the dose estimation from unstable chromosome aberration frequency and the detection limit, d) the scoring procedure for unstable chromosome aberrations used for biological dosimetry, e) the criteria for converting a measured aberration frequency into an estimate of absorbed dose, f) the reporting of results, g) the quality assurance and quality control, h) informative annexes containing sample instructions for requestor, sample questionnaire, sample report, fitting of the low dose-response curve by the method of maximum likelihood and calculating the error of the dose estimate, odds ratio method for cases of suspected exposure to a low dose, a sample calculation and sample data sheet for recording aberrations.

Begin

2022-08-01

WI

00430104

Planned document number

DIN EN ISO 19238

Project number

08000406

Responsible national committee

NA 080-00-01 AA - Dosimetry 

Responsible european committee

CEN/TC 430 - Nuclear energy, nuclear technologies, and radiological protection 

Responsible international committee

ISO/TC 85/SC 2/WG 18 - Biological and physical retrospective dosimetry 

draft standard

Radiological protection - Performance criteria for service laboratories performing biological dosimetry by cytogenetics - The dicentric assay (ISO/DIS 19238:2022); German and English version prEN ISO 19238:2022
2022-12
Order from Beuth Verlag

previous edition(s)

Radiological protection - Performance criteria for service laboratories performing biological dosimetry by cytogenetics (ISO 19238:2014); German version EN ISO 19238:2017
2020-05

Order from Beuth Verlag

Contact

Alexandra Hannawald

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