NA 080

DIN Standards Committee Radiology

Project

Radiological protection - Performance criteria for laboratories using the cytokinesis block micronucleus (CBMN) assay in peripheral blood lymphocytes for biological dosimetry (ISO/FDIS 17099:2024); German version FprEN ISO 17099:2024

Abstract

This document gives guidance on: a) confidentiality of personal information for the customer and the laboratory; b) laboratory safety requirements; c) calibration sources and calibration dose ranges useful for establishing the reference doseresponse curves that contribute to the dose estimation from CBMN assay yields and the detection limit; d) performance of blood collection, culturing, harvesting, and sample preparation for CBMN assay scoring; e) scoring criteria; f) conversion of micronucleus frequency in BNCs into an estimate of absorbed dose; g) reporting of results; h) quality assurance and quality control; i) informative annexes containing sample instructions for customers, sample questionnaire, a microscope scoring data sheet, and a sample report. This document excludes methods for automated scoring of CBMN.

Begin

2021-11-19

WI

00430095

Planned document number

DIN EN ISO 17099

Project number

08000384

Responsible national committee

NA 080-00-01 AA - Dosimetry  

Responsible european committee

CEN/TC 430 - Nuclear energy, nuclear technologies, and radiological protection  

Responsible international committee

ISO/TC 85/SC 2/WG 18 - Biological and physical retrospective dosimetry  

draft standard

Radiological protection - Performance criteria for laboratories using the cytokinesis block micronucleus (CBMN) assay in peripheral blood lymphocytes for biological dosimetry (ISO/DIS 17099:2023); German and English version prEN ISO 17099:2023
2023-09
Order from Beuth Verlag

previous edition(s)

Radiological protection - Performance criteria for laboratories using the cytokinesis block micronucleus (CBMN) assay in peripheral blood lymphocytes for biological dosimetry (ISO 17099:2014); German version EN ISO 17099:2017
2020-03

Order from Beuth Verlag

Contact

Alexandra Hannawald

Alexander-Wellendorff-Str. 2
75172 Pforzheim

Tel.: +49 7231 9188-21

Send message to contact